Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo

被引：273

作者：

Yan, Hong ^{[1
]}

Teh, Cathleen ^{[3
]}

Sreejith, Sivaramapanicker ^{[1
]}

Zhu, Liangliang ^{[1
]}

Kwok, Anna ^{[1
]}

Fang, Weiqin ^{[1
]}

Ma, Xing ^{[2
]}

Kim Truc Nguyen ^{[1
]}

Korzh, Vladimir ^{[3
]}

Zhao, Yanli ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore, Singapore

[3] Natl Univ Singapore, Inst Mol & Cell Biol, Lab Fish Dev Biol, Singapore 117548, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 33期

基金：

新加坡国家研究基金会;

关键词：

drug delivery; mesoporous silica nanoparticles; nanoparticles; photothermal switches; zebrafish; CONTROLLED-RELEASE; GUEST MOLECULES; LIGHT-DRIVEN; ROTAXANES; SURFACE;

D O I：

10.1002/anie.201203993

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans-cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8373 / 8377

页数：5

共 40 条

[11] Enzymatic synthesis and photoswitchable enzymatic cleavage of a peptide-linked rotaxane [J].

Cheetham, AG ;

Hutchings, MG ;

Claridge, TDW ;

Anderson, HL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (10) :1596-1599

[12] Azobenzene-Based Colorimetric Chemosensors for Rapid Naked-Eye Detection of Mercury(II) [J].

Cheng, Xiaohong ;

Li, Qianqian ;

Li, Conggang ;

Qin, Jingui ;

Li, Zhen .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (26) :7276-7281

[13] Impact of Nanotechnology on Drug Delivery [J].

Farokhzad, Omid C. ;

Langer, Robert .

ACS NANO, 2009, 3 (01) :16-20

[14] Light-Operated Mechanized Nanoparticles [J].

Ferris, Daniel P. ;

Zhao, Yan-Li ;

Khashab, Niveen M. ;

Khatib, Hussam A. ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (05) :1686-+

[15] Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles [J].

Glangchai, Luz Cristal ;

Caldorera-Moore, Mary ;

Shi, Li ;

Roy, Krishnendu .

JOURNAL OF CONTROLLED RELEASE, 2008, 125 (03) :263-272

[16] Gated and Near-Surface Diffusion of Charged Fullerenes in Nanochannels [J].

Grattoni, Alessandro ;

Fine, Daniel ;

Zabre, Erika ;

Ziemys, Arturas ;

Gill, Jaskaran ;

Mackeyev, Yuri ;

Cheney, Matthew A. ;

Danila, Delia C. ;

Hosali, Sharath ;

Wilson, Lon J. ;

Hussain, Fazle ;

Ferrari, Mauro .

ACS NANO, 2011, 5 (12) :9382-9391

[17] Template-directed synthesis of donor/acceptor [2]catenanes and [2]rotaxanes [J].

Griffiths, Kirsten E. ;

Stoddart, J. Fraser .

PURE AND APPLIED CHEMISTRY, 2008, 80 (03) :485-506

[18]

Kolb H.C., 2001, ANGEW CHEM, V113, P2056, DOI 10.1002/1521-3757(20010601)113:11

[19]

Kolb HC, 2001, ANGEW CHEM INT EDIT, V40, P2004, DOI 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.3.CO

[20]

2-X

← 1 2 3 4 →