A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei

被引：38

作者：

Waag, DM

McCluskie, MJ

Zhang, NL

Krieg, AM

机构：

[1] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA

[2] Coley Pharmaceut Grp, Wellesley, MA USA

[3] Coley Pharmaceut Grp, Ottawa, ON, Canada

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 03期

关键词：

D O I：

10.1128/IAI.74.3.1944-1948.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

引用

页码：1944 / 1948

页数：5

共 25 条

[21] CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264•7) [J].