Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

被引：16

作者：

Kaneko, H

Neoh, LP

Takeda, N

Akimoto, H

Hishikawa, T

Hashimoto, H

Hirose, S

Karaki, S

Takiguchi, M

Nakauchi, H

Kaneko, Y

Yamamoto, N

Sekigawa, I

机构：

[1] JUNTENDO UNIV,SCH MED,DEPT INTERNAL MED & RHEUMATOL,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO MED & DENT UNIV,SCH MED,DEPT MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

[3] UNIV TOKYO,INST MED SCI,DEPT TUMOR BIOL,MINATO KU,TOKYO 108,JAPAN

[4] UNIV TSUKUBA,INST BASIC MED SCI,DEPT IMMUNOL,TSUKUBA,IBARAKI 305,JAPAN

[5] UNIV TSUKUBA,TARA,TSUKUBA,IBARAKI 305,JAPAN

[6] AJINOMOTO CO INC,TOKYO 104,JAPAN

[7] JUNTENDO UNIV,IZU NAGAOKA HOSP,DEPT MED,IZU NAGAOKA,SHIZUOKA 41022,JAPAN

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 11期

关键词：

D O I：

10.1128/JVI.71.11.8918-8922.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HTV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

引用

页码：8918 / 8922

页数：5

共 42 条

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