No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction

被引：37

作者：

van Mierlo, D. R. J. ^{[1
]}

Penha, T. R. Lopez ^{[1
,4
]}

Schipper, R. J. ^{[1
,2
]}

Martens, M. H. ^{[1
,2
,3
]}

Serroyen, J. ^{[5
]}

Lobbes, M. B. I. ^{[2
,3
]}

Heuts, E. M. ^{[1
]}

Tuinder, S. ^{[4
]}

Smidt, M. L. ^{[1
,3
]}

机构：

[1] Maastricht Univ, Med Ctr Maastricht UMC, Dept Surg, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr Maastricht UMC, Dept Radiol, NL-6202 AZ Maastricht, Netherlands

[3] GROW Sch Oncol & Dev Biol, Maastricht, Netherlands

[4] Maastricht Univ, Med Ctr Maastricht UMC, Dept Plast Surg, NL-6202 AZ Maastricht, Netherlands

[5] Maastricht Univ, Med Ctr Maastricht UMC, Dept Methodol & Stat, NL-6202 AZ Maastricht, Netherlands

来源：

BREAST | 2013年 / 22卷 / 06期

关键词：

Breast cancer; Reconstructive surgical procedure; Local neoplasm recurrence; Post-operative complications; ADJUVANT CHEMOTHERAPY; DELIVERY; IMPACT; TIME;

D O I：

10.1016/j.breast.2013.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy. Method: Patients that underwent IBR after SSM between 2004 and 2011 were included. Results: A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025). Conclusion: In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1166 / 1170

页数：5

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