Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

被引：23

作者：

Yangyuoru, Philip M. ^{[1
]}

Zhang, Amy Y. Q. ^{[2
]}

Shi, Zhe ^{[1
]}

Koirala, Deepak ^{[1
]}

Balasubramanian, Shankar ^{[2
,3
,4
]}

Mao, Hanbin ^{[1
]}

机构：

[1] Kent State Univ, Dept Chem & Biochem, Kent, OH 44242 USA

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Canc Res UK, Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England

[4] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 0SP, England

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 15期

基金：

美国国家科学基金会;

关键词：

G-quadruplexes; laser tweezers; mechanical stability; mechanochemistry; RNA structures; single molecules; TERRA; REPEAT-CONTAINING RNA; K+ SOLUTION; FOLDING PATHWAYS; DNA STRUCTURES; PARALLEL; SEQUENCES; CHEMISTRY; KINETICS; BINDING; BONDS;

D O I：

10.1002/cbic.201300350

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G-quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1931 / 1935

页数：5

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