Influence of solvent and the operating conditions on the crystallization of racemic mandelic acid

被引：33

作者：

Profir, VM ^{[1
]}

Rasmuson, ÅC ^{[1
]}

机构：

[1] Royal Inst Technol, Dept Chem Engn & Technol, SE-10044 Stockholm, Sweden

来源：

CRYSTAL GROWTH & DESIGN | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1021/cg034122p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystallization of racemic mandelic acid is studied in unseeded batch cooling experiments in four solvent systems. Apart from the thermodynamically stable racemic compound, a metastable modification of the racemic compound is also found to initially form upon nucleation. The metastable racemate is characterized by thermal analysis (MDSC), FTIR spectroscopy, and X-ray powder diffraction (XRPD). The experiments show that the type of crystal modification that is formed upon nucleation is strongly influenced by the operating conditions such as filtration, cooling rate, and stirring rate, as well as by the solvent. The solvent effect can be related to the characteristics of the crystal structures of the two modifications, and to the hydrogen bonding properties of the solvent. The crystal structure of the metastable modification of the racemic compound is very similar to that of the pure enantiomer, which explains the similarity of the FTIR spectra, the XRPD diffraction pattern, and the thermodynamic stability.

引用

页码：315 / 323

页数：9

共 30 条

[21] Enantiomeric mandelic acid system-melting point phase diagram and solubility in water [J].

Lorenz, H ;

Sapoundjiev, D ;

Seidel-Morgenstern, A .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2002, 47 (05) :1280-1284

[22]

Mullin JW, 2001, CRYSTALLISATION

[23] REACTIONS OF CRYSTALLINE (R)-(-)-MANDELIC AND (S)-(+)-MANDELIC ACID WITH AMINES - CRYSTAL-STRUCTURE AND DIPOLE-MOMENT OF (S)-MANDELIC ACID - A METHOD OF DETERMINING ABSOLUTE-CONFIGURATION OF CHIRAL CRYSTALS [J].

PATIL, AO ;

PENNINGTON, WT ;

PAUL, IC ;

CURTIN, DY ;

DYKSTRA, CE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (05) :1529-1535

[24]

Prausnitz J.M., 1999, MOL THERMODYNAMIC FL, VThird

[25] Processes and phenomena of purity decrease during the optical resolution of DL-threonine by preferential crystallization [J].

Profir, VM ;

Matsuoka, M .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2000, 164 (2-3) :315-324

[26] Study of the crystallization of mandelic acid in water using in situ ATR-IR spectroscopy [J].

Profir, VM ;

Furusjö, E ;

Danielsson, LG ;

Rasmuson, ÅC .

CRYSTAL GROWTH & DESIGN, 2002, 2 (04) :273-279

[27] CRYSTALLOGRAPHIC DATA .61. DL-MANDELIC ACID [J].

ROSE, HA .

ANALYTICAL CHEMISTRY, 1952, 24 (10) :1680-1680

[28]

Shiraiwa T, 1997, CHIRALITY, V9, P48

[29]

TOYOKURA K, 1999, 14 INT S IND CRYST I

[30] ALPHA-HYDROXYPHENYLACETIC ACID - REDETERMINATION [J].

WEI, KT ;

WARD, DL .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1977, 33 (MAR15) :797-800

← 1 2 3 →