Novel Tn antigen-containing neoglycopeptides: Synthesis and evaluation as anti tumor vaccines

被引：58

作者：

Cipolla, L ^{[1
]}

Rescigno, M ^{[1
]}

Leone, A ^{[1
]}

Peri, F ^{[1
]}

La Ferla, B ^{[1
]}

Nicotra, F ^{[1
]}

机构：

[1] Univ Milan, Dept Biotechnol & Biosci, I-20126 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0968-0896(01)00433-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fully unprotected alpha-C-glycosyl analogue of N-acetylgalactosamine 9 was conjugated by a non-natural oxime bond to the segment peptides (328-340)OVA and (327-339)OVA, affording neoglycopeptides 1-2 and 3, having one or two sugar units, respectively. The three neoglycopeptides were tested in vitro in an antigen presentation assay as antitumor vaccines. Neoglycopeptides 1-3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1639 / 1646

页数：8

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