A recombinant canarypox virus protects rabbits against a lethal rabbit hemorrhagic disease virus (RHDV) challenge

被引：45

作者：

Fischer, L

LeGros, FX

Mason, PW

Paoletti, E

机构：

[1] RHONE MERIEUX,LYON 07,FRANCE

[2] USDA ARS,PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944

来源：

VACCINE | 1997年 / 15卷 / 01期

关键词：

RKDV; canarypox; vaccination;

D O I：

10.1016/S0264-410X(96)00102-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An ALVAC (canarypox)-based recombinant virus ALVAC-RHDV (vCP309) expressing a native rabbit hemorrhagic disease virus (RHDV) capsid protein was derived and assessed for its protective efficacy in rabbits Protection against a lethal RHDV challenge was demonstrated in rabbits inoculated twice with either high (10(7) p.f.u.) or low (10(5) p.f.u.) doses of vCP309. However, animals in the high nose group developed significantly higher antibody response. These results have implications that are relevant to the development of a safe rabbit hemorrhagic disease (RHD) vaccine and further illustrate the utility of the ALVAC vector system to elicit protective immune responses in nonavian species. Copyright (C) 1997 Elsevier Science Ltd.

引用

页码：90 / 96

页数：7

共 32 条

[1]

Arguello Villares JL, 1991, REV SCI TECH OIE, V10, P471

[2] MOLECULAR-CLONING, SEQUENCING AND EXPRESSION IN ESCHERICHIA-COLI OF THE CAPSID PROTEIN GENE FROM RABBIT HEMORRHAGIC-DISEASE VIRUS (SPANISH ISOLATE AST/89) [J].