T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes

被引：64

作者：

Ding, Ling ^{[1
,2
,3
]}

Pfoh, Roland ^{[4
]}

Ruehl, Stephan ^{[4
]}

Qin, Song ^{[2
]}

Laatsch, Hartmut ^{[1
]}

机构：

[1] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[4] Univ Gottingen, Dept Inorgan Chem, D-37077 Gottingen, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 01期

基金：

国家高技术研究发展计划(863计划);

关键词：

D O I：

10.1021/np8006843

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.

引用

页码：99 / 101

页数：3

共 10 条

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SESQUITERPENES OF THE ESSENTIAL OIL OF PINUS-SYLVESTRIS [J].