N-carboxamido-staurosporine and selina-4(14),7(11)-diene-8,9-diol, new metabolites from a marine Streptomyces sp.

被引：39

作者：

Wu, Shao Jie

Fotso, Serge

Li, Fuchao

Qin, Song

Kelter, Gerhard

Fiebig, Heinz H.

Laatsch, Hartmut

机构：

[1] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Qingdao 100049, Peoples R China

[4] Oncotest GmbH, D-79108 Freiburg, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 06期

关键词：

marine streptomycete; staurosporine; selinane sesquiterpene;

D O I：

10.1038/ja.2006.46

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

In our screening of micro-organisms for novel bioactive natural products, a new staurosporinone, N-carboxamido-staurosporine (1c), and a new sesquiterpene, (5S,8S,9R,10S)-selina-4(14),7(11)-diene-8,9-diol (2a), were isolated from the culture broth of the marine-derived Streptomyces sp. QD518. Their structures were determined by spectroscopic methods and by comparison of the NMR data with those of structurally related known natural products, which were isolated from the same strain.

引用

页码：331 / 337

页数：7

共 29 条

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3-(HYDROXYACETYL)INDOLE, A PLANT-GROWTH REGULATOR FROM THE OREGON RED ALGA PRIONITIS-LANCEOLATA [J].