A new indole derivative from the red alga Chondria atropurpurea.: Isolation, structure determination, and anthelmintic activity

被引：88

作者：

Davyt, D

Entz, W

Fernandez, R

Mariezcurrena, R

Mombrú, AW

Saldaña, J

Domínguez, L

Coll, J

Manta, E

机构：

[1] Univ Republ, Fac Quim, Catedra Quim Farmaceut, Montevideo 2124, Uruguay

[2] Univ Republ, Fac Quim, Catedra Cristalog, Montevideo 2124, Uruguay

[3] Univ Republ, Fac Quim, Catedra Farmacol, Montevideo 2124, Uruguay

[4] Univ Republ, Fac Quim, Catedra Bot, Montevideo 2124, Uruguay

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 12期

关键词：

D O I：

10.1021/np980114c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, S-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N-1,N-1-trimethyl derivative of compound 2) against Nippostrongylus brasiliensis in vitro were evaluated.

引用

页码：1560 / 1563

页数：4

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