Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)

被引：27

作者：

Alali, Feras Q. ^{[1
]}

Tahboub, Yahya R. ^{[2
]}

Ibrahim, Eyad S. ^{[2
]}

Qandil, Amjad M. ^{[1
]}

Tawaha, Khaled ^{[3
]}

Burgess, Jason P. ^{[4
,5
]}

Sy, Arlene ^{[4
,5
]}

Nakanishi, Yuka ^{[4
,5
]}

Kroll, David J. ^{[4
,5
]}

Oberlies, Nicholas H. ^{[4
,5
,6
]}

机构：

[1] Jordan Univ Sci & Technol, Fac Pharm, Dept Med Chem & Pharmacognosy, Irbid 22110, Jordan

[2] Jordan Univ Sci & Technol, Fac Sci & Arts, Dept Appl Chem, Irbid 22110, Jordan

[3] Univ Jordan, Fac Pharm, Dept Pharmaceut Sci, Amman 11942, Jordan

[4] Res Triangle Inst, Ctr Organ & Med Chem, Res Triangle Pk, NC 27709 USA

[5] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

[6] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 12期

关键词：

Echium glomeratum; boraginaceae; pyrrolizidine alkaloids; petranine; angeloylretronecine;

D O I：

10.1016/j.phytochem.2008.06.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC(50) values > 20 mu g/ml). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2341 / 2346

页数：6

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