Design, synthesis, and preliminary biological evaluation of novel ketone derivatives of shikimic acid

被引：7

作者：

Jiang, Min ^{[1
,2
]}

Xiong, Bing ^{[2
]}

Shen, Yu-mei ^{[1
]}

Yang, Chunhao ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Syst Biomed, Shanghai Ctr Syst Biomed, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2013年 / 3卷 / 43期

基金：

中国国家自然科学基金;

关键词：

II DEHYDROQUINASE; MYCOBACTERIUM-TUBERCULOSIS; STREPTOMYCES-COELICOLOR; APICOMPLEXAN PARASITES; COMPETITIVE INHIBITORS; ENOLATE INTERMEDIATE; ARYLBORONIC ACIDS; ACYL CHLORIDES; DRUG DESIGN; PATHWAY;

D O I：

10.1039/c3ra43755h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein report the discovery of novel shikimic acid derivatives via Suzuki coupling and Liebeskind-Srogl reaction. Fourteen compounds were synthesized and evaluated against M. tuberculosis H(37)Rv (ATCC 95054). Most of these compounds displayed activities against M. tuberculosis with MIC ranging from 4 to 16 mu g mL(-1). These substances are promising antimycobacterial prototypes.

引用

收藏

页码：20599 / 20605

页数：7

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