(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid:: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases

被引：23

作者：

Frederickson, M

Roszak, AW

Coggins, JR

Lapthorn, AJ

Abell, C

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

[3] Univ Glasgow, Inst Biomed & Life Sci, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 11期

关键词：

D O I：

10.1039/b404535a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occuring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.

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页码：1592 / 1596

页数：5

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