Experiences with the Shikimate-pathway enzymes as targets for rational drug design

被引：73

作者：

Coggins, JR ^{[1
]}

Abell, C

Evan, LB

Frederickson, M

Robinson, DA

Roszak, AW

Lapthorn, AP

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

dehydroquinone; dehydroquinone inhibitor; 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase); 6-fluoroshikimate; rational drug design; shikamate pathway;

D O I：

10.1042/BST0310548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.

引用

页码：548 / 552

页数：5

共 45 条

[1] KINETIC AND STRUCTURAL-ANALYSIS OF ENZYME INTERMEDIATES - LESSONS FROM EPSP SYNTHASE [J].

ANDERSON, KS ;

JOHNSON, KA .

CHEMICAL REVIEWS, 1990, 90 (07) :1131-1149

[2]

Baillie A. C., 1972, Pesticide Science, V3, P113, DOI 10.1002/ps.2780030202

[3] INHIBITION OF CHORISMATE SYNTHASE BY (6R) AND (6S)-6-FLUORO-5-ENOLPYRUVYLSHIKIMATE 3-PHOSPHATE [J].

BALASUBRAMANIAN, S ;

DAVIES, GM ;

COGGINS, JR ;

ABELL, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) :8945-8946

[4] Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase [J].

Bello, CG ;

Harris, JM ;

Manthey, MK ;

Coggins, JR ;

Abell, C .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (05) :407-409

[5] THE SHIKIMATE PATHWAY - A METABOLIC TREE WITH MANY BRANCHES [J].

BENTLEY, R .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1990, 25 (05) :307-384

[6] KINETICS OF 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE INHIBITION BY GLYPHOSATE [J].

BOOCOCK, MR ;

COGGINS, JR .

FEBS LETTERS, 1983, 154 (01) :127-133

[7] ESCHERICHIA-COLI CHORISMATE SYNTHASE CATALYZES THE CONVERSION OF (6S)-6-FLUORO-5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE TO 6-FLUOROCHORISMATE - IMPLICATIONS FOR THE ENZYME MECHANISM AND THE ANTIMICROBIAL ACTION OF (6S)-6-FLUOROSHIKIMATE [J].

BORNEMANN, S ;

RAMJEE, MK ;

BALASUBRAMANIAN, S ;

ABELL, C ;

COGGINS, JR ;

LOWE, DJ ;

THORNELEY, RNF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) :22811-22815

[8] Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis [J].

Carpenter, EP ;

Hawkins, AR ;

Frost, JW ;

Brown, KA .

NATURE, 1998, 394 (6690) :299-302

[9]

CHAUDHURI S, 1991, BIOCHEM J, V275, P1

[10] (6S)-6-FLUOROSHIKIMIC ACID, AN ANTIBACTERIAL AGENT ACTING ON THE AROMATIC BIOSYNTHETIC-PATHWAY [J].

DAVIES, GM ;

BARRETTBEE, KJ ;

JUDE, DA ;

LEHAN, M ;

NICHOLS, WW ;

PINDER, PE ;

THAIN, JL ;

WATKINS, WJ ;

WILSON, RG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :403-406

← 1 2 3 4 5 →