Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

被引：179

作者：

Gueiffier, A

Lhassani, M

Elhakmaoui, A

Snoeck, R

Andrei, G

Chavignon, O

Teulade, JC

Kerbal, A

Essassi, EM

Debouzy, JC

Witvrouw, M

Blache, Y

Balzarini, J

DeClercq, E

Chapat, JP

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

[2] LAB CHIM ORGAN,GRP RECH PHARMACOCHIM,F-63000 CLERMONT FERRAN,FRANCE

[3] UNIV SIDI MOHAMED BEN ABDELLAH,FAC SCI DHAR MAHREZ,CHIM ORGAN LAB,FES,MOROCCO

[4] FAC SCI RABAT,LAB CHIM ORGAN HETEROCYCL,RABAT,MOROCCO

[5] CRSSA,UNITE BIOPHYS,F-38702 LA TRONCHE,FRANCE

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 14期

关键词：

D O I：

10.1021/jm9507901

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

引用

页码：2856 / 2859

页数：4

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