Protein complexes take the bait

被引：107

作者：

Kumar, A ^{[1
]}

Snyder, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

NATURE | 2002年 / 415卷 / 6868期

关键词：

D O I：

10.1038/415123a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many cellular functions are carried out by proteins that are bound together in complexes. In two new large-scale studies, labelled proteins are used as 'bait' to capture and identify those complexes.

引用

页码：123 / 124

页数：2

共 8 条

[1] The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors [J].

Beck, T ;

Hall, MN .

NATURE, 1999, 402 (6762) :689-692

[2] Functional organization of the yeast proteome by systematic analysis of protein complexes [J].

Gavin, AC ;

Bösche, M ;

Krause, R ;

Grandi, P ;

Marzioch, M ;

Bauer, A ;

Schultz, J ;

Rick, JM ;

Michon, AM ;

Cruciat, CM ;

Remor, M ;

Höfert, C ;

Schelder, M ;

Brajenovic, M ;

Ruffner, H ;

Merino, A ;

Klein, K ;

Hudak, M ;

Dickson, D ;

Rudi, T ;

Gnau, V ;

Bauch, A ;

Bastuck, S ;

Huhse, B ;

Leutwein, C ;

Heurtier, MA ;

Copley, RR ;

Edelmann, A ;

Querfurth, E ;

Rybin, V ;

Drewes, G ;

Raida, M ;

Bouwmeester, T ;

Bork, P ;

Seraphin, B ;

Kuster, B ;

Neubauer, G ;

Superti-Furga, G .

NATURE, 2002, 415 (6868) :141-147

[3] 14-3-3-PROTEINS - POTENTIAL ROLES IN VESICULAR TRANSPORT AND RAS SIGNALING IN SACCHAROMYCES-CEREVISIAE [J].

GELPERIN, D ;

WEIGLE, J ;

NELSON, K ;

ROSEBOOM, P ;

IRIE, K ;

MATSUMOTO, K ;

LEMMON, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11539-11543

[4] Affinity of yeast nucleotide excision repair factor 2, consisting of the Rad4 and Rad23 proteins, for ultraviolet damaged DNA [J].

Guzder, SN ;

Sung, P ;

Prakash, L ;

Prakash, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :31541-31546

[5] Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry [J].

Ho, Y ;

Gruhler, A ;

Heilbut, A ;

Bader, GD ;

Moore, L ;

Adams, SL ;

Millar, A ;

Taylor, P ;

Bennett, K ;

Boutilier, K ;

Yang, LY ;

Wolting, C ;

Donaldson, I ;

Schandorff, S ;

Shewnarane, J ;

Vo, M ;

Taggart, J ;

Goudreault, M ;

Muskat, B ;

Alfarano, C ;

Dewar, D ;

Lin, Z ;

Michalickova, K ;

Willems, AR ;

Sassi, H ;

Nielsen, PA ;

Rasmussen, KJ ;

Andersen, JR ;

Johansen, LE ;

Hansen, LH ;

Jespersen, H ;

Podtelejnikov, A ;

Nielsen, E ;

Crawford, J ;

Poulsen, V ;

Sorensen, BD ;

Matthiesen, J ;

Hendrickson, RC ;

Gleeson, F ;

Pawson, T ;

Moran, MF ;

Durocher, D ;

Mann, M ;

Hogue, CWV ;

Figeys, D ;

Tyers, M .

NATURE, 2002, 415 (6868) :180-183

[6] A comprehensive two-hybrid analysis to explore the yeast protein interactome [J].

Ito, T ;

Chiba, T ;

Ozawa, R ;

Yoshida, M ;

Hattori, M ;

Sakaki, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4569-4574

[7] 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S-cerevisiae [J].

Roberts, RL ;

Mosch, HU ;

Fink, GR .

CELL, 1997, 89 (07) :1055-1065

[8] A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae [J].

Uetz, P ;

Giot, L ;

Cagney, G ;

Mansfield, TA ;

Judson, RS ;

Knight, JR ;

Lockshon, D ;

Narayan, V ;

Srinivasan, M ;

Pochart, P ;

Qureshi-Emili, A ;

Li, Y ;

Godwin, B ;

Conover, D ;

Kalbfleisch, T ;

Vijayadamodar, G ;

Yang, MJ ;

Johnston, M ;

Fields, S ;

Rothberg, JM .

NATURE, 2000, 403 (6770) :623-627

← 1 →