Modulation of membrane potential and ionic currents by the AT(1) and AT(2) receptors of angiotensin II

被引：25

作者：

Chorvatova, A

GalloPayet, N

Casanova, C

Payet, MD

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT PHYSIOL & BIOPHYS,SHERBROOKE,PQ J1H 5N4,CANADA

[2] UNIV SHERBROOKE,FAC MED,SERV ENDOCRINOL,SHERBROOKE,PQ J1H 5N4,CANADA

[3] UNIV MONTREAL,SCH OPTOMETRY,MONTREAL,PQ H3C 3J7,CANADA

来源：

CELLULAR SIGNALLING | 1996年 / 8卷 / 08期

关键词：

angiotensin II; ionic currents; membrane potential; action potentials;

D O I：

10.1016/S0898-6568(96)00117-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiotensin II, the principal effector of the renin-angiotensin system, modulates various ionic currents. Its effects on potassium currents, including outward transient potassium current, the inward or outward rectifiers, as well as Ca2+ activated potassium currents, is well described. Other ionic currents, such as voltage-dependent calcium currents, cationic or chloride currents, are also altered by the hormone. All these effects provoke changes in membrane potential, such as modulation of action potential firing or resting membrane potential and control intracellular calcium concentration. Summarized here are the results obtained on these membrane electrical properties using electrophysiological recordings. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：525 / 532

页数：8

共 89 条

[81] ANG-II INHIBITS CALCIUM-ACTIVATED POTASSIUM CHANNELS FROM CORONARY SMOOTH-MUSCLE IN LIPID BILAYERS [J].