Maintenance versus manipulation of information held in working memory: An event-related fMRI study

被引：565

作者：

D'Esposito, M ^{[1
]}

Postle, BR ^{[1
]}

Ballard, D ^{[1
]}

Lease, J ^{[1
]}

机构：

[1] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA

来源：

BRAIN AND COGNITION | 1999年 / 41卷 / 01期

关键词：

functional MRI; working memory; prefrontal cortex;

D O I：

10.1006/brcg.1999.1096

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One model of the functional organization of lateral prefrontal cortex (PFC) in primates posits that this region is organized in a dorsal/ventral fashion subserving spatial and object working memory, respectively. Alternatively, it has been proposed that a dorsal/ventral subdivision of lateral PFC instead reflects the type of processing performed upon information held in working memory. We tested this hypothesis using an event-related fMRI method that can discriminate among functional changes occurring during temporally separated behavioral subcomponents of a single trial. Subjects performed a delayed-response task with two types of trials in which they were required to: (1) retain a sequence of letters across the delay period (maintenance) or (2) reorder the sequence into alphabetical order across the delay period (manipulation). In each subject, activity during the delay period was found in both dorsolateral and ventrolateral PFC in both types of trials. However, dorsolateral PFC activity was greater in manipulation trials. These findings are consistent with the processing model of the functional organization of working memory in PFC. (C) 1999 Academic Press.

引用

页码：66 / 86

页数：21

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