Mannose-binding lectin: The pluripotent molecule of the innate immune system

被引:634
作者
Turner, MW
机构
来源
IMMUNOLOGY TODAY | 1996年 / 17卷 / 11期
关键词
D O I
10.1016/0167-5699(96)10062-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mannose-binding lectin (MBL) is a versatile macromolecule, embodying functional characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a primary infection and during the window of vulnerability experienced by all infants following the decay of maternal antibody. Here, Malcolm Turner reviews recent studies of MBL which suggest the need of reconsider the importance of this protein in the innate immune system.
引用
收藏
页码:532 / 540
页数:11
相关论文
共 76 条
[1]   COMPLEMENT-DEPENDENT NEUTRALIZATION OF INFLUENZA-VIRUS BY A SERUM MANNOSE-BINDING LECTIN [J].
ANDERS, EM ;
HARTLEY, CA ;
READING, PC ;
EZEKOWITZ, RAB .
JOURNAL OF GENERAL VIROLOGY, 1994, 75 :615-622
[2]   PURIFICATION, SUBUNIT CHARACTERIZATION AND ULTRASTRUCTURE OF 3 SOLUBLE BOVINE LECTINS - CONGLUTININ, MANNOSE-BINDING PROTEIN AND THE PENTRAXIN SERUM AMYLOID P-COMPONENT [J].
ANDERSEN, O ;
FRIIS, P ;
NIELSEN, EH ;
VILSGAARD, K ;
LESLIE, RGQ ;
SVEHAG, SE .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1992, 36 (01) :131-141
[3]   CRYSTAL-STRUCTURE AND MOLECULAR-STRUCTURE OF A COLLAGEN-LIKE PEPTIDE AT 1.9-ANGSTROM RESOLUTION [J].
BELLA, J ;
EATON, M ;
BRODSKY, B ;
BERMAN, HM .
SCIENCE, 1994, 266 (5182) :75-81
[4]   MANNOSE-BINDING PROTEIN GENE POLYMORPHISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
DAVIES, EJ ;
SNOWDEN, N ;
HILLARBY, MC ;
CARTHY, D ;
GRENNAN, DM ;
THOMSON, W ;
OLLIER, WER .
ARTHRITIS AND RHEUMATISM, 1995, 38 (01) :110-114
[5]  
DRICKAMER K, 1993, ANNU REV CELL BIOL, V9, P237, DOI 10.1146/annurev.cb.09.110193.001321
[6]   The collectins in innate immunity [J].
Epstein, J ;
Eichbaum, Q ;
Sheriff, S ;
Ezekowitz, RAB .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (01) :29-35
[7]  
EZEKOWITZ R A B, 1991, Current Biology, V1, P60
[8]  
GARRED P, 1993, CLIN EXP IMMUNOL, V94, P99
[9]   INCREASED FREQUENCY OF HOMOZYGOSITY OF ABNORMAL MANNAN-BINDING-PROTEIN ALLELES IN PATIENTS WITH SUSPECTED IMMUNODEFICIENCY [J].
GARRED, P ;
MADSEN, HO ;
HOFMANN, B ;
SVEJGAARD, A .
LANCET, 1995, 346 (8980) :941-943
[10]   DIALLELIC POLYMORPHISM MAY EXPLAIN VARIATIONS OF THE BLOOD-CONCENTRATION OF MANNAN-BINDING PROTEIN IN ESKIMOS, BUT NOT IN BLACK-AFRICANS [J].
GARRED, P ;
MADSEN, HO ;
KURTZHALS, JAL ;
LAMM, LU ;
THIEL, S ;
HEY, AS ;
SVEJGAARD, A .
EUROPEAN JOURNAL OF IMMUNOGENETICS, 1992, 19 (06) :403-412