Mannose-binding lectin: The pluripotent molecule of the innate immune system

被引：634

作者：

Turner, MW

机构：

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 11期

关键词：

D O I：

10.1016/0167-5699(96)10062-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mannose-binding lectin (MBL) is a versatile macromolecule, embodying functional characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a primary infection and during the window of vulnerability experienced by all infants following the decay of maternal antibody. Here, Malcolm Turner reviews recent studies of MBL which suggest the need of reconsider the importance of this protein in the innate immune system.

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页码：532 / 540

页数：11

相关论文

共 76 条

[41] CLEAVAGE OF THE 3RD COMPONENT OF COMPLEMENT (C3) BY MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE-PROTEASE (MASP) WITH SUBSEQUENT COMPLEMENT ACTIVATION [J].

MATSUSHITA, M ;

FUJITA, T .

IMMUNOBIOLOGY, 1995, 194 (4-5) :443-448

[42]

MILLER ME, 1968, LANCET, V2, P60

[43]

OHTA M, 1990, J BIOL CHEM, V265, P1980

[44] ISOLATION AND CHARACTERIZATION OF 2 DISTINCT MANNAN-BINDING PROTEINS FROM RAT SERUM [J].

OKA, S ;

IKEDA, K ;

KAWASAKI, T ;

YAMASHINA, I .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 260 (01) :257-266

[45] A COMMON CONGENITAL IMMUNODEFICIENCY PREDISPOSING TO INFECTION AND ATOPY IN INFANCY [J].

RICHARDSON, VF ;

LARCHER, VF ;

PRICE, JF .

ARCHIVES OF DISEASE IN CHILDHOOD, 1983, 58 (10) :799-802

[46]

ROBERTON DM, 1981, CLIN EXP IMMUNOL, V43, P208

[47] AFFINITY CHROMATOGRAPHY OF HUMAN LIVER ALPHA-D-MANNOSIDASE [J].

ROBINSON, D ;

PHILLIPS, NC ;

WINCHESTER, B .

FEBS LETTERS, 1975, 53 (01) :110-112

[48] THE HUMAN MANNOSE-BINDING PROTEIN GENE - EXON STRUCTURE REVEALS ITS EVOLUTIONARY RELATIONSHIP TO A HUMAN PULMONARY SURFACTANT GENE AND LOCALIZATION TO CHROMOSOME-10 [J].

SASTRY, K ;

HERMAN, GA ;

DAY, L ;

DEIGNAN, E ;

BRUNS, G ;

MORTON, CC ;

EZEKOWITZ, RAB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1175-1189

[49] CHARACTERIZATION OF MURINE MANNOSE-BINDING PROTEIN GENES MBL1 AND MBL2 REVEALS FEATURES COMMON TO OTHER COLLECTIN GENES [J].

SASTRY, R ;

WANG, JS ;

BROWN, DC ;

EZEKOWITZ, RAB ;

TAUBER, AI ;

SASTRY, KN .

MAMMALIAN GENOME, 1995, 6 (02) :103-110

[50]

SCHLENZ S, 1996, INFECT IMMUN, V63, P3360

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