In vitro and in vivo anti-inflammatory effects of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides

被引:58
作者
Fan, Huaying [1 ]
Qi, Dong [2 ]
Yang, Mingyan [3 ]
Fang, Hui [1 ]
Liu, Ke [1 ,3 ]
Zhao, Feng [1 ]
机构
[1] Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China
[2] Yantai Yu Huang Ding Hosp, Yantai 264000, Shandong, Peoples R China
[3] Shandong Target Drug Res Co Ltd, Yantai 264005, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
Picrasma quassioides Bennet; 4-Methoxy-5-hydroxycanthin-6-one; Anti-inflammation; NITRIC-OXIDE; ARTHRITIS; CYTOKINES; LAPPA;
D O I
10.1016/j.phymed.2012.11.016
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-alpha induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis. (C) 2012 Elsevier GmbH. All rights reserved.
引用
收藏
页码:319 / 323
页数:5
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