In vitro and in vivo anti-inflammatory effects of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides

被引：58

作者：

Fan, Huaying ^{[1
]}

Qi, Dong ^{[2
]}

Yang, Mingyan ^{[3
]}

Fang, Hui ^{[1
]}

Liu, Ke ^{[1
,3
]}

Zhao, Feng ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China

[2] Yantai Yu Huang Ding Hosp, Yantai 264000, Shandong, Peoples R China

[3] Shandong Target Drug Res Co Ltd, Yantai 264005, Shandong, Peoples R China

来源：

PHYTOMEDICINE | 2013年 / 20卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

Picrasma quassioides Bennet; 4-Methoxy-5-hydroxycanthin-6-one; Anti-inflammation; NITRIC-OXIDE; ARTHRITIS; CYTOKINES; LAPPA;

D O I：

10.1016/j.phymed.2012.11.016

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-alpha induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：319 / 323

页数：5

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