Odorless Isocyanide Chemistry: An Integrated Microfluidic System for a Multistep Reaction Sequence

被引：98

作者：

Sharma, Siddharth ^{[1
]}

Maurya, Ram Awatar ^{[1
]}

Min, Kyoung-Ik ^{[1
]}

Jeong, Guan-Young ^{[1
]}

Kim, Dong-Pyo ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, POSTECH, Dept Chem Engn, Pohang 790784, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 29期

基金：

新加坡国家研究基金会;

关键词：

continuous flow; isocyanides; microreactors; multi-component reactions; organometallics; CONTINUOUS-FLOW SYNTHESIS; MULTICOMPONENT REACTIONS; NITROGEN LIGANDS; EFFICIENT; SAFE; COMPLEXES; INSERTION; BOND;

D O I：

10.1002/anie.201303213

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7564 / 7568

页数：5

共 64 条

[1] Isocyanide-based multicomponent reactions in drug discovery [J].