Exploiting the dual reactivity of o-isocyanobenzamide:: Three-component synthesis of 4-imino-4H-3,1-benzoxazines

被引：64

作者：

Bonne, D ^{[1
]}

Dekhane, M

Zhu, JP

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] AstraZeneca PR&D, Macclesfield SK10 2NA, Cheshire, England

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 23期

关键词：

D O I：

10.1021/ol052239w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A multicomponent synthesis of 4-imino-4H-3,1-benzoxazines is developed. Heating a toluene solution of an aldehyde (6), an amine (7), and an isonitrile (5) in the presence of a stoichiometric amount of ammonium chloride at 60 degrees C for 12 h produces the title compound in good to excellent yields.

引用

页码：5285 / 5288

页数：4

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