Recent advances in isocyanide-based multicomponent chemistry

被引：515

作者：

Dömling, A ^{[1
]}

机构：

[1] Morphochem AG, D-81379 Munich, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(02)00328-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. MCRs that involve isocyanides are by far the most versatile reactions in terms of scaffolds and number of accessible compounds.

引用

页码：306 / 313

页数：8

共 23 条

[1] Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors [J].