Ammonium chloride promoted Ugi four-component, five-center reaction of α-substituted α-isocyano acetic acid:: A strong solvent effect

被引：48

作者：

Bonne, D ^{[1
]}

Dekhane, M

Zhu, JP

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 25期

关键词：

D O I：

10.1021/ol0479388

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conditions have been developed for the multicomponent synthesis of di- and tetrapeptide (7) based on the unique reactivity of a-isocyano acetic acid (4 and its alpha-substituted derivatives) by an Ugi four-component, five-center reaction. Simply mixing 4, a carbonyl compound (aldehyde or ketone, 8), and a secondary amine (9) (ratio: 1:1:2) in toluene in the presence of 1.5 equiv of ammonium chloride afforded the desired product in good to excellent yield as a mixture of two diastereomers.

引用

页码：4771 / 4774

页数：4

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