Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

被引：318

作者：

Slupska, MM

Baikalov, C

Luther, WM

Chiang, JH

Wei, YF

Miller, JH

机构：

[1] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[3] HUMAN GENOME SCI,ROCKVILLE,MD 20850

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 13期

关键词：

D O I：

10.1128/jb.178.13.3885-3892.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have cloned the human mutY gene (hMYH) from both genomic and cDNA libraries. The human gene contains 15 introns and is 7.1 kb long. The 16 exons encode a protein of 535 amino acids that displays 41% identity to the Escherichia coli protein, which provides an important function in the repair of oxidative damage to DNA and helps to prevent mutations from oxidative lesions. The human mutY gene maps on the short arm of chromosome 1, between p32.1 and p34.3.

引用

页码：3885 / 3892

页数：8

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