In vivo 13C NMR spectroscopy and metabolic modeling in the brain:: a practical perspective

被引：72

作者：

Henry, PG ^{[1
]}

Adriany, G ^{[1
]}

Deelchand, D ^{[1
]}

Gruetter, R ^{[1
]}

Marjanska, M ^{[1
]}

Öz, G ^{[1
]}

Seaquist, ER ^{[1
]}

Shestov, A ^{[1
]}

Ugurbil, K ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

来源：

MAGNETIC RESONANCE IMAGING | 2006年 / 24卷 / 04期

关键词：

C-13 NMR spectroscopy; metabolic modeling; TCA cycle; glutamatergic neurotransmission; compartmentation;

D O I：

10.1016/j.mri.2006.01.003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In vivo C-13 NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the C-13 labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：527 / 539

页数：13

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