In vivo 13C NMR spectroscopy and metabolic modeling in the brain:: a practical perspective

被引：72

作者：

Henry, PG ^{[1
]}

Adriany, G ^{[1
]}

Deelchand, D ^{[1
]}

Gruetter, R ^{[1
]}

Marjanska, M ^{[1
]}

Öz, G ^{[1
]}

Seaquist, ER ^{[1
]}

Shestov, A ^{[1
]}

Ugurbil, K ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

来源：

MAGNETIC RESONANCE IMAGING | 2006年 / 24卷 / 04期

关键词：

C-13 NMR spectroscopy; metabolic modeling; TCA cycle; glutamatergic neurotransmission; compartmentation;

D O I：

10.1016/j.mri.2006.01.003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In vivo C-13 NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the C-13 labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：527 / 539

页数：13

共 52 条

[11] Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo:: On the correlation of total glucose consumption with glutamatergic action [J].

Choi, IY ;

Lei, HX ;

Gruetter, R .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (11) :1343-1351

[12] In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism [J].

de Graaf, RA ;

Mason, GF ;

Patel, AB ;

Behar, KL ;

Rothman, DL .

NMR IN BIOMEDICINE, 2003, 16 (6-7) :339-357

[13] Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H[13C]-NMR spectroscopy [J].

de Graaf, RA ;

Brown, PB ;

Mason, GF ;

Rothman, DL ;

Behar, KL .

MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (01) :37-46

[14] Investigating brain metabolism at high fields using localized 13C NMR spectroscopy without 1H decoupling [J].

Deelchand, DK ;

Ugurbil, K ;

Henry, PG .

MAGNETIC RESONANCE IN MEDICINE, 2006, 55 (02) :279-286

[15]

DENHOLLANDER JA, 1979, P NATL ACAD SCI USA, V76, P6096

[16] REGIONAL CEREBRAL GLUCOSE-UTILIZATION DURING HYPERGLYCEMIA [J].

DUCKROW, RB ;

BRYAN, RM .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (03) :989-993

[17]

Garcia PA, 2004, EPILEPSIA, V45, P2

[18] Localized in vivo 13C NMR spectroscopy of the brain [J].

Gruetter, R ;

Adriany, G ;

Choi, IY ;

Henry, PG ;

Lei, HX ;

Öz, GL .

NMR IN BIOMEDICINE, 2003, 16 (6-7) :313-338

[19] Broadband decoupled, H-1-localized C-13 MRS of the human brain at 4 Tesla [J].

Gruetter, R ;

Adriany, G ;

Merkle, H ;

Andersen, PM .

MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :659-664

[20] Localized in vivo 13C-NMR of glutamate metabolism in the human brain:: Initial results at 4 Tesla [J].

Gruetter, R ;

Seaquist, ER ;

Kim, S ;

Ugurbil, K .

DEVELOPMENTAL NEUROSCIENCE, 1998, 20 (4-5) :380-388

← 1 2 3 4 5 6 →