Platelet-derived growth factor (PDGF) and glial tumorigenesis

被引：153

作者：

Shih, AH

Holland, EC

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Surg Neurosurg, New York, NY 10021 USA

来源：

CANCER LETTERS | 2006年 / 232卷 / 02期

关键词：

platelet-derived growth factor; central nervous systern; gliomas;

D O I：

10.1016/j.canlet.2005.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platelet-derived growth factor (PDGF) has long been implicated in cancer and is known to be involved in many biological processes. In Central Nervous System (CNS) neoplasms, particularly gliomas, PDGF is often over-expressed. However, what role PDGF plays in tumor progression remains to be fully described. A wide range of work from in vitro studies to mouse models have implicated the PDGF pathway in various processes including proliferation, cellular migration, development, and angiogenesis. Being a secreted factor, PDGF not only has autocrine effects on producing cells but also has potential for paracrine effects on other tumor cells and the tumor microenvironment. The development of small molecules that inhibit the PDGF receptor and various subsequent signaling components promises, to introduce new approaches to the treatment of gliomas. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：139 / 147

页数：9

共 57 条

[21]

Heller S, 2000, INT J CANCER, V85, P211

[22]

HERMANSON M, 1992, CANCER RES, V52, P3213

[23]

Hesselager G, 2003, CANCER RES, V63, P4305

[24] Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice [J].