Biosynthesis of natural products on modular peptide synthetases

被引:61
作者
Doekel, S [1 ]
Marahiel, MA [1 ]
机构
[1] Univ Marburg, Fachbereich Chem Biochem, D-35032 Marburg, Germany
关键词
D O I
10.1006/mben.2000.0170
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Microbial nonribosomally processed peptides represent a large class of natural products including numerous important pharmaceutical agents, as well as other representatives that play a prevalent role in pathogenicity of certain microorganisms [NI. A. Marahiel, T. Stachelhaus, and H. D. Mootz (1997). Chem. Rev. 97, 2651-2673]. Although diverse in structure, nonribosomally synthesized peptides have a common mode of biosynthesis. They are assembled on very large protein templates called peptide synthetases that exhibit a modular organization, allowing polymerization of monomers in an assembly-line-like mechanism. (C) 2001 Academic Press.
引用
收藏
页码:64 / 77
页数:14
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