A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells

被引：78

作者：

Warashina, M

Min, KH

Kuwabara, T

Huynh, A

Gage, FH

Schultz, PG

Ding, S

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Salk Inst Biol Studies, San Diego, CA 92186 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 04期

关键词：

drug design; neurochemistry; neuronal differentiation; neuropathiazol; stem cells;

D O I：

10.1002/anie.200503089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Brain power: An image-based screen of a chemical library was carried out to identify molecules that regulate the differentiation of adult rat hippocampal neural stem cells. Neuropathiazol (1) induces selective neuronal differentiation and competitively suppresses astrocyte differentiation. This compound should be a useful tool to study the processes that control stem-cell fate both in vitro and in vivo. © 2006 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

收藏

页码：591 / 593

页数：3

相关论文

共 12 条

[1] Adult neurogenesis: From precursors to network and physiology [J].

Abrous, DN ;

Koehl, M ;

Le Moal, M .

PHYSIOLOGICAL REVIEWS, 2005, 85 (02) :523-569

[2] Vertebrate neurogenesis is counteracted by Sox1-3 activity [J].

Bylund, M ;

Andersson, E ;

Novitch, BG ;

Muhr, J .

NATURE NEUROSCIENCE, 2003, 6 (11) :1162-1168

[3] Neurogenesis in the adult human hippocampus [J].

Eriksson, PS ;

Perfilieva, E ;

Björk-Eriksson, T ;

Alborn, AM ;

Nordborg, C ;

Peterson, DA ;

Gage, FH .

NATURE MEDICINE, 1998, 4 (11) :1313-1317

[4] IGF-1 instructs multipotent adult neural progenitor cells to become oligodendrocytes [J].

Hsieh, J ;

Aimone, JB ;

Kaspar, BK ;

Kuwabara, T ;

Nakashima, K ;

Gage, FH .

JOURNAL OF CELL BIOLOGY, 2004, 164 (01) :111-122

[5] Increased hippocampal neurogenesis in Alzheimer's disease [J].

Jin, KL ;

Peel, AL ;

Mao, XO ;

Xie, L ;

Cottrell, BA ;

Henshall, DC ;

Greenberg, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :343-347

[6] A small modulatory dsRNA specifies the fate of adult neural stem cells [J].

Kuwabara, T ;

Hsieh, J ;

Nakashima, K ;

Taira, K ;

Gage, FH .

CELL, 2004, 116 (06) :779-793

[7] Neurogenesis in the adult brain: New strategies for central nervous system diseases [J].

Lie, DC ;

Song, HJ ;

Colamarino, SA ;

Ming, GL ;

Gage, FH .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :399-421

[8] Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy [J].

Liu, M ;

Pleasure, SJ ;

Collins, AE ;

Noebels, JL ;

Naya, FJ ;

Tsai, MJ ;

Lowenstein, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :865-870

[9] Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 [J].

Nakashima, K ;

Yanagisawa, M ;

Arakawa, H ;

Kimura, N ;

Hisatsune, T ;

Kawabata, M ;

Miyazono, K ;

Taga, T .

SCIENCE, 1999, 284 (5413) :479-482

[10] The adult rat hippocampus contains primordial neural stem cells [J].

Palmer, TD ;

Takahashi, J ;

Gage, FH .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1997, 8 (06) :389-404