A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells

被引：78

作者：

Warashina, M

Min, KH

Kuwabara, T

Huynh, A

Gage, FH

Schultz, PG

Ding, S

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Salk Inst Biol Studies, San Diego, CA 92186 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 04期

关键词：

drug design; neurochemistry; neuronal differentiation; neuropathiazol; stem cells;

D O I：

10.1002/anie.200503089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Brain power: An image-based screen of a chemical library was carried out to identify molecules that regulate the differentiation of adult rat hippocampal neural stem cells. Neuropathiazol (1) induces selective neuronal differentiation and competitively suppresses astrocyte differentiation. This compound should be a useful tool to study the processes that control stem-cell fate both in vitro and in vivo. © 2006 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

页码：591 / 593

页数：3