Long-term health-related quality of life following surgery for oesophageal cancer

被引:130
作者
Djarv, T. [1 ]
Lagergren, J. [1 ]
Blazeby, J. M. [2 ,3 ]
Lagergren, P. [1 ,2 ,3 ]
机构
[1] Karolinska Inst, Dept Mol Med & Surg, Unit Oesophageal & Gastr Res, Stockholm, Sweden
[2] Univ Bristol, Dept Social Med, Bristol, Avon, England
[3] Univ Bristol, Dept Clin Sci, Bristol, Avon, England
基金
瑞典研究理事会;
关键词
D O I
10.1002/bjs.6293
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer. Methods: A Swedish nationwide cohort of patients undergoing oesophagectomy for cancer between April 2001 and January 2004 was studied prospectively, and compared with a Swedish age- and sex-adjusted reference population. Validated European Organisation for Research and Treatment of Cancer quality of life questionnaires were used to assess HRQL at 6 months and 3 years after surgery. A mean score difference of 10 or more between groups was considered clinically relevant and tested further for statistical significance. Results: Of 358 patients, 117 (32.7 per cent) survived for at least 3 years. Of these, 87 patients (74.4 per cent) responded to the questionnaires. Six months after surgery, most aspects of HRQL were substantially worse than in the reference population with no improvement at 3 years. Patients alive at 3 years reported significantly poorer role and social function, and significantly more problems with fatigue, diarrhoea, appetite loss, nausea and vomiting, than in the reference population. Conclusion: HRQL in long-term survivors after oesophagectomy does not improve between 6 months and 3 years after surgery, and is worse than that in a comparable reference population.
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页码:1121 / 1126
页数:6
相关论文
共 23 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]  
[Anonymous], 2010, TNM CLASSIFICATION M
[3]   Quality of life during potentially curative treatment for locally advanced oesophageal cancer [J].
Avery, K. N. L. ;
Metcalfe, C. ;
Barham, C. P. ;
Alderson, D. ;
Falk, S. J. ;
Blazeby, J. M. .
BRITISH JOURNAL OF SURGERY, 2007, 94 (11) :1369-1376
[4]   Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma [J].
Blazeby, JM ;
Sanford, E ;
Falk, SJ ;
Alderson, D ;
Donovan, JL .
CANCER, 2005, 103 (09) :1791-1799
[5]   Clinical and psychometric validation of an EORTC questionnaire module, the EORTC QLQ-OES18, to assess quality of life in patients with oesophageal cancer [J].
Blazeby, JM ;
Conroy, T ;
Hammerlid, E ;
Fayers, P ;
Sezer, O ;
Koller, M ;
Arraras, J ;
Bottomley, A ;
Vickery, CW ;
Etienne, PL ;
Alderson, D .
EUROPEAN JOURNAL OF CANCER, 2003, 39 (10) :1384-1394
[6]   Feasibility of quality of life assessment in patients with upper gastrointestinal tract cancer [J].
Blazeby, JM ;
Nicklin, J ;
Brookes, ST ;
Winstone, K ;
Alderson, D .
BRITISH JOURNAL OF CANCER, 2003, 89 (03) :497-501
[7]  
Blazeby JM, 2000, CANCER, V88, P1781
[8]   Prospective analysis of quality of life after surgical resection for esophageal cancer: Preliminary results [J].
Brooks, JA ;
Kesler, KA ;
Johnson, CS ;
Ciaccia, D ;
Brown, JW .
JOURNAL OF SURGICAL ONCOLOGY, 2002, 81 (04) :185-194
[9]   Quality of life in long-term survivors after curative transhiatal oesophagectomy for oesophageal carcinoma [J].
de Boer, AGEM ;
Genovesi, PIO ;
Sprangers, MAG ;
van Sandick, JW ;
Obertop, H ;
van Lanschot, JJB .
BRITISH JOURNAL OF SURGERY, 2000, 87 (12) :1716-1721
[10]   Quality of life after transhiatal compared with extended transthoracic resection for adenocarcinoma of the esophagus [J].
de Boer, AGEM ;
van Lanschot, JJB ;
van Sandick, JW ;
Hulscher, JBF ;
Stalmeier, PFM ;
de Haes, JCJM ;
Tilanus, HW ;
Obertop, H ;
Sprangers, MAG .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (20) :4202-4208