Novel strategies targeting cancer stem cells through phytochemicals and their analogs

被引:68
作者
Dandawate, Prasad [1 ]
Padhye, Subhash [1 ,2 ]
Ahmad, Aamir [2 ]
Sarkar, Fazlul H. [2 ,3 ]
机构
[1] Univ Pune, ISTRA, Dept Chem, Abeda Inamdar Senior Coll, Pune 411001, Maharashtra, India
[2] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Sch Med, Dept Pathol, Detroit, MI 48201 USA
[3] Wayne State Univ, Dept Oncol, Barbara Ann Karmanos Canc Inst, Sch Med, Detroit, MI 48201 USA
关键词
Cancer stem cells; Phytochemicals; CDF; Notch; EMT; EPITHELIAL-MESENCHYMAL TRANSITION; CASPASE-MEDIATED APOPTOSIS; WNT/BETA-CATENIN-PATHWAY; TUMOR-INITIATING CELLS; SIDE POPULATION CELLS; PROSTATE-CANCER; PANCREATIC-CANCER; BREAST-CANCER; BETA-CATENIN; DOWN-REGULATION;
D O I
10.1007/s13346-012-0079-x
中图分类号
TH7 [仪器、仪表];
学科分类号
080401 [精密仪器及机械];
摘要
Cancer stem cells (CSCs) are cells that exist within a tumor with a capacity of self-renewal and an ability to differentiate, giving rise to heterogeneous populations of cancer cells. These cells are increasingly being implicated in resistance to conventional therapeutics and have also been implicated in tumor recurrence. Several cellular signaling pathways including Notch, Wnt, phosphoinositide-3kinase- Akt-mammalian target of rapamycin pathways, and known markers such as CD44, CD133, CD166, ALDH, etc. have been associated with CSCs. Here, we have reviewed our current understanding of self-renewal pathways and factors that help in the survival of CSCs with special emphasis on those that have been documented to be modulated by well characterized natural agents such as curcumin, sulforaphane, resveratrol, genistein, and epigallocatechin gallate. With the inclusion of a novel derivative of curcumin, CDF, we showcase how natural agents can be effectively modified to increase their efficacy, particularly against CSCs. We hope that this article will generate interest among researchers for further mechanistic and clinical studies exploiting the cancer preventive and therapeutic role of nutraceuticals by targeted elimination of CSCs.
引用
收藏
页码:165 / 182
页数:18
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