Developmental expression profiles of Celsr (Flamingo) genes in the mouse

被引：72

作者：

Tissir, F ^{[1
]}

De-Backer, O ^{[1
]}

Goffinet, AM ^{[1
]}

de Rouvroit, CL ^{[1
]}

机构：

[1] Fac Univ Notre Dame Paix, Neurobiol Unit 2853, B-5000 Namur, Belgium

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 112卷 / 1-2期

关键词：

brain development; cerebral cortex; cadherin; in situ hybridization; genomic structure; frizzled; flamingo; G-protein coupled receptor;

D O I：

10.1016/S0925-4773(01)00623-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：157 / 160

页数：4

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