Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes

被引：15

作者：

Bialoszewska, Agata ^{[1
,2
]}

Baychelier, Florence ^{[3
,4
]}

Niderla-Bielinska, Justyna ^{[1
]}

Czop, Andrzej ^{[5
]}

Debre, Patrice ^{[3
,4
]}

Vieillard, Vincent ^{[3
,4
]}

Kieda, Claudine ^{[2
]}

Malejczyk, Jacek ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Histol & Embryol, Ctr Biostruct Res, PL-02004 Warsaw, Poland

[2] Univ Orleans, Ctr Biophys Mol, CNRS UPR 4301, Orleans, France

[3] Hop La Pitie Salpetriere, INSERM, UMR S Immunite & Infect 945, Paris, France

[4] Univ Paris 06, Paris, France

[5] Prof J Bogdanowicz Childrens Hosp, Dept Trauma & Orthopaed Surg, Warsaw, Poland

来源：

CELLULAR IMMUNOLOGY | 2013年 / 285卷 / 1-2期

关键词：

Articular chondrocytes; Cartilage; NK cells; NKp44; receptor; ligand; NK CELLS; CYTOTOXICITY;

D O I：

10.1016/j.cellimm.2013.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NI( cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal human articular chondrocytes constitutively express a ligand for NKp44, one of stimulatory NK cell receptors involved in recognition and killing of target cells. Expression of NKp44 ligand by normal articular chondrocytes is not involved in their killing by unstimulated NK cells; however, it is responsible for anti-chondrocyte cytotoxicity mediated by long-term activated NK cells. Thus, expression of NKp44 ligand may play a role in chondrocyte destruction in course of chronic inflammatory cartilage disorders. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：6 / 9

页数：4

共 15 条

[1]

Chondrocyte-specific phenotype confers susceptibility of rat chondrocytes to lysis by NK cells [J].