Effects of luteal estradiol pre-treatment on the outcome of IVF in poor ovarian responders

被引:22
作者
Chang, Xiaoxia [1 ,2 ]
Wu, Jie [1 ,2 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China
关键词
In vitro fertilization; luteal estradiol treatment; ovarian stimulation; poor responder; IN-VITRO FERTILIZATION; ANTAGONIST SUPPRESSION PROTOCOL; ORAL-CONTRACEPTIVE PILL; FLARE-UP-PROTOCOL; GONADOTROPIN STIMULATION; GNRH ANTAGONISTS; HORMONE AGONIST; PHASE; HYPERSTIMULATION; PATCH;
D O I
10.3109/09513590.2012.736558
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: In view of the discrepancies about the luteal estradiol treatment before stimulation protocols having some potential advantages compared with the standard protocols in poor ovarian responders undergoing IVF, a meta-analysis of the published data was performed to compare the efficacy of the luteal estradiol pre-treatment protocols in IVF poor response patients. Methods: We searched for all published articles. The searches yielded 32 articles, from which seven studies met the inclusion criteria. We performed this meta-analysis involving 450 IVF patients in luteal estradiol pre-treatment protocol group and 606 patients in standard protocol group. Results: The luteal estradiol protocol resulted in a significantly higher duration of stimulation compared with the standard protocol. In addition, the number of oocytes retrieved and mature oocytes retrieved were significantly higher in the luteal estradiol protocols than those in the standard protocols. The cycle cancellation rate (CCR) in the luteal estradiol protocols was lower than the standard protocols. Moreover, no significant difference was found in the clinical pregnancy rate (CPR). Conclusions: The addition of the estradiol in the luteal phase preceding IVF in poor responders improved IVF cycle outcomes, including increasing the number of oocytes retrieved and mature oocytes retrieved and decreasing the CCR.
引用
收藏
页码:196 / 200
页数:5
相关论文
共 35 条
[1]   Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial [J].
Akman, MA ;
Erden, HF ;
Tosun, SB ;
Bayazit, N ;
Aksoy, E ;
Bahceci, M .
HUMAN REPRODUCTION, 2001, 16 (05) :868-870
[2]   GnRH antagonist in assisted reproduction: a Cochrane review [J].
Al-Inany, H ;
Aboulghar, M .
HUMAN REPRODUCTION, 2002, 17 (04) :874-885
[3]   Follicular synchronization using transdermal estradiol patch and GnRH antagonists in the luteal phase; does it increase oocyte yield in poor responders to gonadotropin stimulation for in vitro fertilization (IVF)? A comparative study with microdose flare-up protocol [J].
Ata, Baris ;
Zeng, Xing ;
Son, Weon Y. ;
Holzer, Hananel ;
Tan, Seang L. .
GYNECOLOGICAL ENDOCRINOLOGY, 2011, 27 (11) :876-879
[4]   Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients [J].
Battaglia, C ;
Salvatori, M ;
Maxia, N ;
Petraglia, F ;
Facchinetti, F ;
Volpe, A .
HUMAN REPRODUCTION, 1999, 14 (07) :1690-1697
[5]   Effect of estrogen priming through luteal phase and stimulation phase in poor responders in in-vitro fertilization [J].
Chang, Eun Mi ;
Han, Ji Eun ;
Won, Hyung Jae ;
Kim, You Shin ;
Yoon, Tae Ki ;
Lee, Woo Sik .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2012, 29 (03) :225-230
[6]   Will GnRH antagonists provide new hope for patients considered 'difficult responders' to GnRH agonist protocols? [J].
Craft, I ;
Gorgy, A ;
Hill, J ;
Menon, D ;
Podsiadly, B .
HUMAN REPRODUCTION, 1999, 14 (12) :2959-2962
[7]   Synchronization of endogenous and exogenous FSH stimuli in controlled ovarian hyperstimulation (COH) [J].
de Ziegler, D ;
Jääskeläinen, AS ;
BRioschi, PA ;
Fanchin, R ;
Bulletti, C .
HUMAN REPRODUCTION, 1998, 13 (03) :561-564
[8]   THE PROGNOSTIC IMPORTANCE OF THE NUMBER OF OOCYTES RETRIEVED AND ESTRADIOL LEVELS IN POOR AND NORMAL RESPONDERS IN INVITRO FERTILIZATION (IVF) TREATMENT [J].
DOR, J ;
SEIDMAN, DS ;
BENSHLOMO, I ;
LEVRAN, D ;
KARASIK, A ;
MASHIACH, S .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1992, 9 (03) :228-232
[9]   Use of a luteal estradiol patch and a gonadotropin-releasing hormone antagonist suppression protocol before gonadotropin stimulation for in vitro fertilization in poor responders [J].
Dragisic, KG ;
Davis, OK ;
Fasouliotis, SJ ;
Rosenwaks, Z .
FERTILITY AND STERILITY, 2005, 84 (04) :1023-1026
[10]   Coordination of early antral follicles by luteal estradiol administration provides a basis for alternative controlled ovarian hyperstimulation regimens [J].
Fanchin, R ;
Cunha, JS ;
Schonäuer, LM ;
Kadoch, IJ ;
Cohen-Bacri, P ;
Frydman, R .
FERTILITY AND STERILITY, 2003, 79 (02) :316-321