Lipoprotein-associated phospholipase A2 and measures of extracoronary atherosclerosis - The Rotterdam study

被引：58

作者：

Kardys, I ^{[1
]}

Oei, HHS ^{[1
]}

van der Meer, IM ^{[1
]}

Hofman, A ^{[1
]}

Breteler, MMB ^{[1
]}

Witteman, JCM ^{[1
]}

机构：

[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2006年 / 26卷 / 03期

关键词：

atherosclerosis; inflammation; lipoprotein-associated phospholipase A2; epidemiology;

D O I：

10.1161/01.ATV.0000201289.83256.cf

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective - Lipoprotein-associated phospholipase A2 ( Lp-PLA2) may be a new and independent predictor of cardiovascular events. The effect of Lp-PLA2 may be exerted through effects of the enzyme on the development of atherosclerosis. Therefore, we investigated the association between Lp-PLA2 activity and measures of extracoronary atherosclerosis. Methods and Results - Lp-PLA2 activity was determined in a random sample of 1820 participants from the Rotterdam Study, a population-based cohort study in men and women >= 55 years. Common carotid intima-media thickness, carotid plaques, ankle-arm index, and aortic calcification were examined. Atherosclerosis status could be assigned in 1609 participants. The age-adjusted odds ratio of having atherosclerosis at any site for the highest versus the lowest tertile of Lp-PLA2 activity was 1.86 ( 95% CI, 1.01 to 3.43) in men and 1.60 ( 95% CI, 1.08 to 2.37) in women. After additional adjustment for cholesterol, these associations attenuated or even disappeared. The odds ratios of having atherosclerosis at specific sites ( carotid arteries and aortic-iliac-femoral tract) followed a similar pattern. Conclusions - Although Lp-PLA2 has been found to be independently associated with cardiovascular events, the association with measures of subclinical extracoronary atherosclerosis found in this study strongly attenuated or even disappeared after adjustment for cholesterol.

引用

页码：631 / 636

页数：6

共 27 条

[11] Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults -: The CARDIA study [J].

Iribarren, C ;

Gross, MD ;

Darbinian, JA ;

Jacobs, DR ;

Sidney, S ;

Loria, CM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (01) :216-221

[12] Association between Lp-PLA2 and coronary artery disease:: Focus on its relationship with lipoproteins and markers of inflammation and hemostasis [J].

Khuseyinova, N ;

Imhof, A ;

Rothenbacher, D ;

Trischler, G ;

Kuelb, S ;

Scharnagl, H ;

Maerz, W ;

Brenner, H ;

Koenig, W .

ATHEROSCLEROSIS, 2005, 182 (01) :181-188

[13] Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population -: Results from the 14-year follow-up of a large cohort from southern Germany [J].

Koenig, W ;

Khuseyinova, N ;

Löwel, H ;

Trischler, G ;

Meisinger, C .

CIRCULATION, 2004, 110 (14) :1903-1908

[14] Use of ankle brachial pressure index to predict cardiovascular events and death: A cohort study [J].

Leng, GC ;

Fowkes, FGR ;

Lee, AJ ;

Dunbar, J ;

Housley, E ;

Ruckley, CV .

BMJ-BRITISH MEDICAL JOURNAL, 1996, 313 (7070) :1440-1444

[15] Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein:: use of a novel inhibitor [J].

Macphee, CH ;

Moores, KE ;

Boyd, HF ;

Dhanak, D ;

Ife, RJ ;

Leach, CA ;

Leake, DS ;

Milliner, KJ ;

Patterson, RA ;

Suckling, KE ;

Tew, DG ;

Hickey, DMB .

BIOCHEMICAL JOURNAL, 1999, 338 :479-487

[16] Peripheral arterial disease in the elderly - The Rotterdam study [J].

Meijer, WT ;

Hoes, AW ;

Rutgers, D ;

Bots, ML ;

Hofman, A ;

Grobbee, DE .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (02) :185-192

[17] Ankle-arm index as a predictor of cardiovascular disease and mortality in the cardiovascular health study [J].

Newman, AB ;

Shemanski, L ;

Manolio, TA ;

Cushman, M ;

Mittelmark, M ;

Polak, JF ;

Powe, NR ;

Siscovick, D .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (03) :538-545

[18] Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults [J].

O'Leary, DH ;

Polak, JF ;

Kronmal, RA ;

Manolio, TA ;

Burke, GL ;

Wolfson, SK .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (01) :14-22

[19] Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke - The Rotterdam Study [J].

Oei, HHS ;

van der Meer, IM ;

Hofman, A ;

Koudstaal, PJ ;

Stijnen, T ;

Breteler, MMB ;

Witteman, JCM .

CIRCULATION, 2005, 111 (05) :570-575

[20] Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. [J].

Packard, CJ ;

O'Reilly, DSJ ;

Caslake, MJ ;

McMahon, AD ;

Ford, I ;

Cooney, J ;

Macphee, CH ;

Suckling, KE ;

Krishna, M ;

Wilkinson, FE ;

Rumley, A ;

Lowe, GDO .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (16) :1148-1155

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