International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens

被引：65

作者：

Weinmayr, G. ^{[1
]}

Forastiere, F. ^{[5
]}

Weiland, S. K. ^{[1
]}

Rzehak, P. ^{[1
,2
,3
]}

Abramidze, T. ^{[7
]}

Annesi-Maesano, I. ^{[8
]}

Bjoerksten, B. ^{[9
]}

Brunekreef, B. ^{[10
,11
]}

Buechele, G. ^{[1
]}

Cookson, W. O. C. ^{[12
]}

von Mutius, E. ^{[4
]}

Pistelli, R. ^{[6
]}

Strachan, D. P. ^{[13
]}

机构：

[1] Univ Ulm, Inst Epidemiol, D-89075 Ulm, Germany

[2] Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Epidemiol, Neuherberg, Germany

[3] Univ Munich, Inst Med Data Management Biometr & Epidemiol, Munich, Germany

[4] Univ Munich, Dr von Haunersches Univ Childrens Hosp, Munich, Germany

[5] Local Hlth Author Rome, Dept Epidemiol, Rome, Italy

[6] Catholic Univ, Dept Resp Physiol, Rome, Italy

[7] Ctr Allergy & Immunol, Tbilisi, Georgia

[8] Med Sch St Antoine, EPAR, INSERM, U707, Paris, France

[9] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[10] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[11] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[12] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England

[13] Univ London, London, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2008年 / 32卷 / 05期

关键词：

International Study of Asthma and Allergies in Childhood Phase Two study; perennial; population attributable risk; rhinitis; seasonal; skin-prick test;

D O I：

10.1183/09031936.00157807

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The relative importance of atopy in the aetiology of rhinitis is largely unknown. The present study investigated the geographical variations in rhinitis in relation to atopy. The cross-sectional study involved 54,178 children (aged 8-12 yrs) from 30 study centres in 22 countries worldwide. Symptoms of rhinoconjunctivitis and rhinitis without conjunctivitis in the last 12 months were reported in parental questionnaires and children were skin-prick tested. The prevalence of rhinoconjunctivitis and rhinitis without conjunctivitis varied widely (1.5-24.5% and 1.4-45.2%, respectively). For rhinoconjunctivitis, the population attributable fraction (PAF) varied 0-71% for a positive skin-prick test to one or more seasonal allergens and 0-41% for perennial allergens. The PAF for sensitisation to seasonal and perennial allergens was higher in affluent countries (36 and 25%, respectively) than nonaffluent countries (1.3 and 12.6%, respectively). For rhinitis without conjunctivitis, the PAF for perennial allergens was 8 and 4% for affluent and nonaffluent countries, respectively. No significant PAF was found for seasonal allergens. Overall, atopy explained only a limited proportion of rhinitis symptoms, suggesting that the importance of other environmental factors has been under emphasised, particularly in less affluent countries. Atopy seems to be only marginally relevant for rhinitis without conjunctivitis, which seems mainly to reflect nonatopic rhinitis.

引用

页码：1250 / 1261

页数：12

共 36 条

[21] Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China [J].