Microelectrode arrays for electrophysiological monitoring of hippocampal organotypic slice cultures

被引：58

作者：

Thiebaud, P ^{[1
]}

deRooij, NF ^{[1
]}

KoudelkaHep, M ^{[1
]}

Stoppini, L ^{[1
]}

机构：

[1] UNIV GENEVA,DEPT PHARMACOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 1997年 / 44卷 / 11期

关键词：

electrophysiology; microelectrode array; organotypic cultures; perforated substrate;

D O I：

10.1109/10.641344

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A three-dimensional platinum (Pt) microelectrode array embedded on a micromachined silicon (Si) substrate (porosity of 13%, via hole diameter of 40 mu m) has been developed. Electrodes are 35-mu m wide and 20-mu m high, spaced 200 mu m apart and arranged in an elliptic geometry. Integrated within a microperfusion chamber, the devices were used for stimulation and recording experiments of hippocampal slice cultures over a period of several days.

引用

页码：1159 / 1163

页数：5

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