Microelectrode arrays for electrophysiological monitoring of hippocampal organotypic slice cultures

被引:57
作者
Thiebaud, P [1 ]
deRooij, NF [1 ]
KoudelkaHep, M [1 ]
Stoppini, L [1 ]
机构
[1] UNIV GENEVA,DEPT PHARMACOL,CH-1211 GENEVA 4,SWITZERLAND
关键词
electrophysiology; microelectrode array; organotypic cultures; perforated substrate;
D O I
10.1109/10.641344
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A three-dimensional platinum (Pt) microelectrode array embedded on a micromachined silicon (Si) substrate (porosity of 13%, via hole diameter of 40 mu m) has been developed. Electrodes are 35-mu m wide and 20-mu m high, spaced 200 mu m apart and arranged in an elliptic geometry. Integrated within a microperfusion chamber, the devices were used for stimulation and recording experiments of hippocampal slice cultures over a period of several days.
引用
收藏
页码:1159 / 1163
页数:5
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