Neuropeptide FF reduces food intake in rats

被引：101

作者：

Murase, T

Arima, H

Kondo, K

Oiso, Y

机构：

[1] First Dept. of Internal Medicine, Nagoya University School of Medicine, Nagoya 466, 65 Tsurumai-cho, Showa-ku

来源：

PEPTIDES | 1996年 / 17卷 / 02期

关键词：

neuropeptide FF; feeding; opioid; naloxone;

D O I：

10.1016/0196-9781(95)02137-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of neuropeptide FF (NPFF), a mammalian FMRFamide-like peptide with antiopioid activity, on food intake was investigated in food-deprived rat. The ICV administration of NPFF (5 or 10 mu g/rat) reduced food intake during the first 60 min after administration. ICV injection of naloxone (10 or 100 mu g/rat), an opioid antagonist, also decreased food intake. However, the combination of NPFF and naloxone showed no additivity in the anorexigenic effect, suggesting that NPFF and naloxone reduced food intake by the common mechanism. These results indicate that NPFF may function as an endogenous anorexigenic peptide with anitiopioid function.

引用

页码：353 / 354

页数：2

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