MicroRNA-24 induces cisplatin resistance by targeting PTEN in human tongue squamous cell carcinoma

被引：57

作者：

Zheng, Xiangqian ^{[1
]}

Li, Jiansen ^{[2
]}

Peng, Chen ^{[1
]}

Zhao, Jingzhu ^{[1
]}

Chi, Jiadong ^{[1
]}

Meng, Xiangrui ^{[3
]}

Yun, Xinwei ^{[1
]}

Li, Dapeng ^{[2
]}

Yu, Yang ^{[1
]}

Gao, Ming ^{[1
]}

Li, Yigong ^{[1
]}

机构：

[1] Tianjin Med Univ, Dept Thyroid & Neck Tumor, Canc Inst & Hosp, Oncol Key Lab Canc Prevent & Therapy,Natl Clin Re, Tianjin 300060, Peoples R China

[2] Tianjin Med Univ, Dept Anesthesiol, Canc Inst & Hosp, Oncol Key Lab Canc Prevent & Therapy,Natl Clin Re, Tianjin 300060, Peoples R China

[3] Tianjin Med Univ, Dept Lyphoma, Canc Inst & Hosp, Oncol Key Lab Canc Prevent & Therapy,Natl Clin Re, Tianjin 300060, Peoples R China

来源：

ORAL ONCOLOGY | 2015年 / 51卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MicroRNA-24; PTEN; Cisplatin resistance; Tongue squamous carcinoma; IN-VIVO; CANCER; PROLIFERATION; PATHWAY; CHEMORESISTANCE; METASTASIS; MECHANISM; BINDING;

D O I：

10.1016/j.oraloncology.2015.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: miR-24 is one of the most significantly up-regulated miRNAs in tongue squamous cell carcinoma (TSCC). PTEN plays an important role in the cell survival and cisplatin resistance of multiple cancers. However, it remains unclear what role does function and mechanism of miR-24 and PTEN play in TSCC. Methodology/principal findings: In this study, miR-24 expression was detected in 79 cases of paired TSCC and normal tissues and 8 TSCC cell lines by real-time PCR and the relevance between miR-24 expression and clinicopathological parameters were analyzed. Further, we demonstrated that deregulation of miR-24 was found to associate with high grade and late stage tumor. In addition, miR-24 induces cell survival and cisplatin resistance through targeting 3'-UTR region of the PTEN, which leads to downregulation of PTEN protein and activation of Akt pro-survival pathway. Conclusions/significance: In conclusion, our results demonstrated that deregulation of miR-24 is a recurrent event in human tongue squamous cell carcinoma and associate with tumor progression and that miR-24 induces cell survival and cisplatin resistance primarily through targeting PTEN/Akt pathway. Thus, miR-24 could be important targets for intervention of this malignancy. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：998 / 1003

页数：6

共 35 条

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miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration [J].