Muscle-derived stem cells

被引：244

作者：

Jankowski, RJ

Deasy, BM

Huard, J

机构：

[1] Univ Pittsburgh, Growth & Dev Lab, Childrens Hosp Pittsburgh, Dept Bioengn, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Orthopaed Surg Mol Genet & Biochem, Pittsburgh, PA USA

来源：

GENE THERAPY | 2002年 / 9卷 / 10期

关键词：

skeletal muscle; stem cells; differentiation; dystrophin;

D O I：

10.1038/sj.gt.3301719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The existence of cells with stem cell-like abilities derived from various tissues can now be extended to include the skeletal muscle compartment. Although researchers have focused on the utilization of these cells with regard to their myogenic capacity, initially exploring more efficient cellular therapy treatments for muscular dystrophy, it is becoming increasingly apparent that such cells may one day be used in the treatment of non-myogenic disorders. Evidence regarding the existence and differentiation capacity of muscle-derived stem cells is discussed, along with current theories regarding their proposed position within the myogenic hierarchy.

引用

收藏

页码：642 / 647

页数：6

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