DCP-1, a Drosophila cell death protease essential for development

被引：273

作者：

Song, ZW

McCall, K

Steller, H

机构：

[1] MIT,DEPT BRAIN & COGNIT SCI,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02139

[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

SCIENCE | 1997年 / 275卷 / 5299期

关键词：

D O I：

10.1126/science.275.5299.536

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apoptosis, a form of cellular suicide, involves the activation of CED-3-related cysteine proteases (caspases), The regulation of caspases by apoptotic signals and the precise mechanism by which they kill the cell remain unknown. In Drosophila, different death-inducing stimuli induce the expression of the apoptotic activator reaper. Cell killing by reaper and two genetically linked apoptotic activators, hid and grim, requires caspase activity. A Drosophila caspase, named Drosophila caspase-1 (DCP-1), was identified and found to be structurally and biochemically similar to Caenorhabditis elegans CED-3. Loss of zygotic DCP-1 function in Drosophila caused larval lethality and melanotic tumors, showing that this gene is essential for normal development.

引用

页码：536 / 540

页数：5

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