Synthesis of new fluidity-enhanced amphiphilic compounds for soluble protein two-dimensional crystallization purpose

被引：11

作者：

Nuss, S ^{[1
]}

Mioskowski, C ^{[1
]}

Lebeau, L ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, CNRS, Lab Synthese Bioorgan, F-67401 Illkirch Graffenstaden, France

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1999年 / 103卷 / 1-2期

关键词：

amphiphile synthesis; ether lipids; branched lipids; fluorinated lipids; monolayer fluidity; protein two-dimensional crystallization;

D O I：

10.1016/S0009-3084(99)00088-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of new amphiphilic compounds is described. The structures are rationally designed for soluble protein two-dimensional (2D) crystallization purpose. Special attention is devoted to fluidity properties expected of resulting monolayers. A series of 13 compounds was prepared containing unsaturated, branched or fluorinated alkyl chains. Structures are either symmetrical or dissymmetrical and present a hydroxyl group as polar head, eventually complemented with two other 'secondary' hydrophilic functions. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：21 / 35

页数：15

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