Insights into the activation mechanism of the visual receptor rhodopsin

被引：13

作者：

Smith, Steven O. ^{[1
]}

机构：

[1] SUNY Stony Brook, Struct Biol Ctr, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

基金：

美国国家卫生研究院;

关键词：

G-protein-coupled receptor (GPCR); retinal chromophore; rhodopsin; solid-slate NMR; transmembrane helix; vision; PROTEIN-COUPLED RECEPTOR; CRYSTAL-STRUCTURE; ADRENERGIC-RECEPTOR; PIGMENT RHODOPSIN; OPSIN; COMPLEX; MEMBRANE; LOCATION; AGONIST; STATE;

D O I：

10.1042/BST20110751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in the structural biology of GPCRs (G-protein-coupled receptors) have provided insights into their structure and function. Comparisons of the visual and ligand-activated receptors highlight the unique elements of rhodopsin that allow it to function as a highly sensitive dim-light photoreceptor in vertebrates, as well as the common elements that it shares with the large class A GPCR family. However, despite progress, a number of questions remain unanswered about how these receptors are activated.

引用

页码：389 / 393

页数：5

共 41 条

[1] Location of the Retinal Chromophore in the Activated State of Rhodopsin [J].

Ahuja, Shivani ;

Crocker, Evan ;

Eilers, Markus ;

Hornak, Viktor ;

Hirshfeld, Amiram ;

Ziliox, Martine ;

Syrett, Natalie ;

Reeves, Philip J. ;

Khorana, H. Gobind ;

Sheves, Mordechai ;

Smith, Steven O. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (15) :10190-10201

[2] Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation [J].

Ahuja, Shivani ;

Hornak, Viktor ;

Yan, Elsa C. Y. ;

Syrett, Natalie ;

Goncalves, Joseph A. ;

Hirshfeld, Amiram ;

Ziliox, Martine ;

Sakmar, Thomas P. ;

Sheves, Mordechai ;

Reeves, Philip J. ;

Smith, Steven O. ;

Eilers, Markus .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (02) :168-175

[3] Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor [J].

Bokoch, Michael P. ;

Zou, Yaozhong ;

Rasmussen, Soren G. F. ;

Liu, Corey W. ;

Nygaard, Rie ;

Rosenbaum, Daniel M. ;

Fung, Juan Jose ;

Choi, Hee-Jung ;

Thian, Foon Sun ;

Kobilka, Tong Sun ;

Puglisi, Joseph D. ;

Weis, William I. ;

Pardo, Leonardo ;

Prosser, R. Scott ;

Mueller, Luciano ;

Kobilka, Brian K. .

NATURE, 2010, 463 (7277) :108-U121

[4] Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist [J].

Chien, Ellen Y. T. ;

Liu, Wei ;

Zhao, Qiang ;

Katritch, Vsevolod ;

Han, Gye Won ;

Hanson, Michael A. ;

Shi, Lei ;

Newman, Amy Hauck ;

Javitch, Jonathan A. ;

Cherezov, Vadim ;

Stevens, Raymond C. .

SCIENCE, 2010, 330 (6007) :1091-1095

[5] Crystal structure of metarhodopsin II [J].

Choe, Hui-Woog ;

Kim, Yong Ju ;

Park, Jung Hee ;

Morizumi, Takefumi ;

Pai, Emil F. ;

Krauss, Norbert ;

Hofmann, Klaus Peter ;

Scheerer, Patrick ;

Ernst, Oliver P. .

NATURE, 2011, 471 (7340) :651-U137

[6] MECHANISM OF ACTIVATION AND INACTIVATION OF OPSIN - ROLE OF GLU(113) AND LYS(296) [J].

COHEN, GB ;

OPRIAN, DD ;

ROBINSON, PR .

BIOCHEMISTRY, 1992, 31 (50) :12592-12601

[7] CONSTITUTIVE ACTIVATION OF OPSIN - INFLUENCE OF CHARGE AT POSITION-134 AND SIZE AT POSITION-296 [J].

COHEN, GB ;

YANG, T ;

ROBINSON, PR ;

OPRIAN, DD .

BIOCHEMISTRY, 1993, 32 (23) :6111-6115

[8] RELIEF OF OPSIN DESENSITIZATION AND PROLONGED EXCITATION OF ROD PHOTORECEPTORS BY 9-DESMETHYLRETINAL [J].

CORSON, DW ;

CORNWALL, MC ;

MACNICHOL, EF ;

TSANG, S ;

DERGUINI, F ;

CROUCH, RK ;

NAKANISHI, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :6958-6962

[9] Location of Trp265 in metarhodopsin II: Implications for the activation mechanism of the visual receptor rhodopsin [J].

Crocker, E ;

Eilers, M ;

Ahuja, S ;

Hornak, V ;

Hirshfeld, A ;

Sheves, M ;

Smith, SO .

JOURNAL OF MOLECULAR BIOLOGY, 2006, 357 (01) :163-172

[10] Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function [J].

Deupi, Xavier ;

Kobilka, Brian K. .

PHYSIOLOGY, 2010, 25 (05) :293-303

← 1 2 3 4 5 →