Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers

被引：154

作者：

Baugh, SDP ^{[1
]}

Yang, ZW ^{[1
]}

Leung, DK ^{[1
]}

Wilson, DM ^{[1
]}

Breslow, R ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 50期

关键词：

D O I：

10.1021/ja011709o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind to a group of cyclodextrin dimers with a carbon-carbon double bond in the linker. The complexes are soluble in water. On irradiation in the presence of oxygen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipitation of the sensitizers. This process concentrates the sensitizers in the light beam, a process that has useful potential in photodynamic therapy.

引用

页码：12488 / 12494

页数：7