A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat

被引：76

作者：

Åhlander, M

Misane, I

Schött, PA

Ögren, SO ^{[1
]}

机构：

[1] Karolinska Inst, Div Cellular & Mol Neurochem, Dept Neurosci, S-17177 Stockholm, Sweden

[2] Latvian Inst Organ Synthesis, Pharmacol Lab, Riga, Latvia

来源：

NEUROPSYCHOPHARMACOLOGY | 1999年 / 21卷 / 03期

关键词：

MK-801; NMDA receptors; hippocampus; spatial learning; hidden platform; cued platform; motor performance; sensory processing;

D O I：

10.1016/S0893-133X(98)00116-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01-0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform were used: with or without local cite. Retention was tested either 24 h or 7 days after training as a probe trial (without platform). The present data indicate that MK-801 produces an impairment of spatial learning that cannot be dissociated from motor or sensory mechanisms. These findings support the view that NMDA receptors probably contribute to, but are not essential for, spatial learning in the water maze. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：414 / 426

页数：13

共 55 条

[41] Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: Nonspatial pretraining eliminates spatial learning deficits [J].