Genetic variation in susceptibility to endocrine disruption by estrogen in mice

被引：203

作者：

Spearow, JL ^{[1
]}

Doemeny, P ^{[1
]}

Sera, R ^{[1
]}

Leffler, R ^{[1
]}

Barkley, M ^{[1
]}

机构：

[1] Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA

来源：

SCIENCE | 1999年 / 285卷 / 5431期

关键词：

D O I：

10.1126/science.285.5431.1259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large (more than 16-fold) differences in susceptibility to disruption of juvenile male reproductive development by 17 beta-estradiol (E-2) were detected between strains of mice. Effects of strain, E-2 dose, and the interaction of strain and E-2 dose on testes weight and spermatogenesis were all highly significant (P < 0.0001). Spermatid maturation was eliminated by low doses of E-2 in strains such as C57BL/6J and C17/Jls. In contrast, mice of the widely used CD-1 line, which has been selected for large litter size, showed Little or no inhibition of spermatid maturation even in response to 16 times as much E-2. Product safety bioassays conducted with animals selected for fecundity may greatly underestimate disruption of male reproductive development by estradiol and environmental estrogenic compounds.

引用

页码：1259 / 1261

页数：3

共 32 条

[1] POTENTIAL OF TESTOSTERONE BUCICLATE FOR MALE CONTRACEPTION - ENDOCRINE DIFFERENCES BETWEEN RESPONDERS AND NONRESPONDERS
BEHRE, HM
BAUS, S
KLIESCH, S
KECK, C
SIMONI, M
NIESCHLAG, E
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (08) : 2394 - 2403
[2] BlancoRodriguez J, 1997, J REPROD FERTIL, V110, P61, DOI 10.1530/jrf.0.1100061
[3] BRADFORD GE, 1968, GENETICS, V58, P283
[4] BRADFORD GE, 1969, GENETICS, V61, P905
[5] BRADFORD GE, 1991, REPROD DOMEST ANIM, P605
[6] THE RESPONSE OF INBRED MICE TO OESTROGENS
CLARINGBOLD, PJ
BIGGERS, JD
[J]. JOURNAL OF ENDOCRINOLOGY, 1955, 12 (01) : 9 - 14
[7] Davis DL, 1997, ENVIRON HEALTH PERSP, V105, P571
[8] ERICKSON S, 1995, BIOL REPROD S1, V52, P70
[9] Relationship between induction of mammary tumors and change of testicular functions in male rats following gamma-ray irradiation and/or diethylstilbestrol
Inano, H
Suzuki, K
Onoda, M
Wakabayashi, K
[J]. CARCINOGENESIS, 1996, 17 (02) : 355 - 360
[10] A VARIETY OF ENVIRONMENTALLY PERSISTENT CHEMICALS, INCLUDING SOME PHTHALATE PLASTICIZERS, ARE WEAKLY ESTROGENIC
JOBLING, S
REYNOLDS, T
WHITE, R
PARKER, MG
SUMPTER, JP
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 (06) : 582 - 587

← 1 2 3 4 →